Byron Caughey Selected Research

PrPC Proteins

4/2012	New generation QuIC assays for prion seeding activity.
8/2007	Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein.
3/2006	Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides.
4/2003	The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein.
3/2002	Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes.

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Byron Caughey Research Topics

Disease

62	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2022 - 03/2002
35	Scrapie 01/2022 - 03/2002
19	Infections 01/2021 - 03/2002
15	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2003
11	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 11/2020 - 02/2009
10	Parkinson Disease (Parkinson's Disease) 01/2022 - 09/2015
10	Sporadic Creutzfeldt-Jakob Disease 01/2021 - 02/2012
9	Chronic Wasting Disease 11/2019 - 01/2006
7	Synucleinopathies 01/2022 - 01/2018
5	Proteostasis Deficiencies 11/2019 - 10/2006
5	Bovine Spongiform Encephalopathy (Mad Cow Disease) 09/2016 - 02/2009
4	Tauopathies 01/2022 - 01/2015
4	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 06/2005
3	Dementia (Dementias) 01/2021 - 01/2018
3	Acquired CJD 01/2020 - 01/2016
3	Amyloid Plaque 10/2015 - 06/2005
3	Brain Diseases (Brain Disorder) 10/2015 - 04/2010
3	Neuroblastoma 01/2014 - 05/2003
2	Multiple System Atrophy 01/2022 - 09/2020
2	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 09/2020
2	Chronic Traumatic Encephalopathy 01/2020 - 01/2019
2	Pick Disease of the Brain (Pick's Disease) 01/2020 - 01/2017
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2020 - 01/2020
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2020 - 11/2019
2	Conversion Disorder (Astasia Abasia) 01/2011 - 03/2002
1	Cognitive Dysfunction 01/2021
1	Parkinsonian Disorders (Parkinsonism) 01/2020
1	Corticobasal Degeneration 01/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2019
1	Fatal Familial Insomnia 01/2017
1	Nervous System Diseases (Neurological Disorders) 01/2017
1	Neuroinflammatory Diseases 01/2016
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2016
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2013
1	Amyloidosis 05/2008

Drug/Important Bio-Agent (IBA)

58	PrionsIBA 01/2022 - 05/2005
47	Prion ProteinsIBA 01/2021 - 09/2002
20	PrPSc ProteinsIBA 01/2017 - 03/2002
16	Peptide Hydrolases (Proteases)FDA Link 11/2017 - 03/2002
15	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2003
13	Amyloid (Amyloid Fibrils)IBA 08/2019 - 06/2005
11	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2012
8	SynucleinsIBA 01/2022 - 01/2018
7	Protein Isoforms (Isoforms)IBA 01/2019 - 03/2002
5	PrPC ProteinsIBA 04/2012 - 03/2002
3	Protein AggregatesIBA 01/2022 - 01/2003
3	alpha-SynucleinIBA 11/2021 - 01/2021
3	Codon (Codons)IBA 08/2019 - 01/2017
3	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 04/2012 - 01/2006
3	PorphyrinsIBA 12/2007 - 01/2006
2	Biological ProductsIBA 01/2021 - 10/2015
2	Pharmaceutical PreparationsIBA 01/2019 - 11/2016
2	Hazardous Substances (Hazardous Materials)IBA 11/2018 - 11/2016
2	Lysine (L-Lysine)FDA Link 09/2017 - 08/2015
2	Polysaccharides (Glycans)IBA 05/2011 - 01/2010
2	Detergents (Detergent)IBA 05/2010 - 03/2006
1	ferric oxide (iron oxide)IBA 01/2021
1	brazilinIBA 01/2021
1	Amyloidogenic ProteinsIBA 01/2020
1	thioflavin TIBA 01/2020
1	Glial Fibrillary Acidic ProteinIBA 08/2019
1	Phosphopyruvate Hydratase (Enolase)IBA 08/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	Antisense OligonucleotidesIBA 01/2019
1	tau Proteins (tau Protein)IBA 01/2017
1	Sodium Chloride FDA LinkGeneric 03/2016
1	Dihydrotachysterol (AT 10)IBA 03/2016
1	AntibodiesIBA 01/2016
1	EpitopesIBA 01/2016
1	ImmunosorbentsIBA 01/2016
1	Peptides (Polypeptides)IBA 01/2016
1	EnzymesIBA 01/2016
1	Proline (L-Proline)FDA Link 08/2015
1	Heparin (Liquaemin)FDA LinkGeneric 06/2014
1	Pathogen-Associated Molecular Pattern MoleculesIBA 04/2014
1	PACAP-related peptideIBA 01/2014
1	Tetracycline (Achromycin)FDA LinkGeneric 04/2012
1	Tannic Acid FDA Link 04/2012
1	Complement System Proteins (Complement)IBA 02/2012
1	PhosphatidylserinesIBA 02/2012
1	Annexin A5IBA 02/2012
1	Carrier Proteins (Binding Protein)IBA 02/2012
1	BuffersIBA 05/2010
1	SaltsIBA 05/2010
1	Carisoprodol (Soma)FDA LinkGeneric 04/2010
1	HydrogenIBA 09/2009
1	DeuteriumIBA 09/2009
1	TetrapyrrolesIBA 11/2007
1	Basic Amino Acids (Basic Amino Acid)IBA 08/2006
1	Glutamine (L-Glutamine)FDA Link 08/2006
1	OligonucleotidesIBA 08/2006
1	ChloridesIBA 01/2006
1	Doxycycline (Periostat)FDA LinkGeneric 01/2006
1	IndiumIBA 01/2006
1	Indicators and Reagents (Reagents)IBA 01/2006
1	tetraphenylporphine sulfonate (TPPS)IBA 01/2006

Therapy/Procedure

7	Therapeutics 01/2019 - 05/2003
1	Injections 01/2019
1	Transplantation 11/2018
1	Blood Transfusion (Blood Transfusions) 01/2011